Ischemic stroke in a patient with interatrial block: Is it only a coincidence or a clear relationship?

Atrial fibrillation (AF) can be detected in nearly 25% of all patients with stroke by sequentially combining different electrocardiographic methods. Prediction of early cardio-embolic stroke remain a permanent challenge in everyday practice. The early identification of an increased risk for atrial fibrillation episodes (which are frequently asymptomatic) is essential for the prevention of cardioembolic events. One of the noninvasive modalities of atrial fibrillation prediction is represented by the electrocardiographic P-wave analysis. This includes study and diagnosis of interatrial conduction block. Our short case report presents a case with ischemic cortico-sottocortical stroke involving capsulo and caudo regions in a woman patient with interatrial block as realized by electrocardiographic P analysis.

Interatrial Conduction Block in an Obstructive Sleep Apnea Patient: An Electrical Premonitor of Atrial Fibrillation.

Obstructive sleep apnea (OSA) is an important sleep disorder and is associated with increased cardiovascular morbidity and mortality. Several recent studies have demonstrated an association OSA and atrial fibrillation (AF). Therefore, it is of great importance understanding the pathophysiological substrate and the interaction between OSA and AF. Moreover, it is well accepted that interatrial block (IAB), evaluated not only by the P-wave duration but also by the P-wave morphology, has the potential to give information about the anatomical substrate predisposing to AF. OSA and AF share many risk factors and comorbidities, including older age, male gender, obesity, hypertension, heart failure, and coronary artery diseases. IAB is defined when the P-wave is ≥120 ms which signifies excessive time for sinus impulses to conduct from the right atrium to the left atrium and may predict future AF events. Accordingly, recent studies have suggested that OSA is associated with atrial functional and structural remodeling which indeed are associated with increased risk of AF. We speculate that IAB, a known factor to predict future AF episodes, may associate with OSA and contribute to the development of arrhythmic events. In the present case, the report presents a woman with OSA and IAB on the surface electrocardiogram (ECG)automatic P-wave analysis and some short episodes of AF in the external event recorder monitoring.

Apical ballooning syndrome or Takotsubo cardiomyopathy: a new challenge in acute cardiac care.

Apical ballooning syndrome (ABS) is a unique acute cardiac syndrome characterized by symptoms and electrocardiographic changes that mimic acute myocardial infarction. It occurs in patients without evidence of significant obstructive coronary artery disease and is associated with transient extensive wall motion abnormalities of the apical and mid portions of the left ventricle. The onset of ABS is preceded by a stressful event, either emotional or physical in around 65% of cases. The underlying pathophysiology for ABS remains unclear; however, several mechanisms have been proposed including multivessel epicardial spasm, microvascular spasm, catecholamine induced myocardial stunning and myocarditis. The treatment of ABS remains entirely empirical and should be individualized according to the patient's clinical picture at the time of presentation. It should be initially managed according to the guidelines for acute coronary syndrome. Once the diagnosis of ABS is made, supportive care usually leads to spontaneous recovery. The prognosis of patients with Takotsubo cardiomyopathy is generally favourable. The left ventricular systolic dysfunction usually resolves within a few weeks. In-hospital mortality is low, less than 2%, and recurrence rate is no more than 10%. The aim of this article is to clarify, for the clinicians dealing with acute cardiac care, when they should suspect ABS and how they should confirm the diagnosis and subsequently manage it.

Ebstein's anomaly: a potential cause of misinterpretation of myocardial perfusion scintigraphy.

We present the case of a 43-year-old woman with a history of Ebstein's anomaly, who was referred for a myocardial perfusion single-photon emission computed tomography (SPECT) study due to angina-like symptoms. Dilatation of the right ventricle and right atrium, apical displacement of the septal tricuspid leaflet, small left ventricle with good left ventricular and a moderate degree of tricuspid regurgitation with mild pulmonary hypertension were found on echocardiography. Myocardial SPECT perfusion imaging with [99m Tc]tetrofosmin demonstrated a large defect in the inferior septal wall in the stress study with mild partial reversibility at rest. Coronary angiography revealed normal coronary arteries. Histological studies have shown that these patients develop increased fibrosis in the left ventricular wall and ventricular septum, especially in the basal and middle region of the septum, which adjoins with the atrialized component of the right ventricle. This is in concordance with the findings of the myocardial perfusion scan in the case described.

Diabetes mellitus: evaluation of patients with known or suspected coronary artery disease and the role played by myocardial perfusion imaging.

Type 2 diabetes markedly increases cardiovascular risk, and patients often present with advanced and asymptomatic disease. The fact that diabetes is associated with an increased risk of acute coronary events and poor long-term survival makes a strong case for detecting coronary artery disease early, perhaps before clinical manifestation in this patient population. This article examines the role of myocardial perfusion scintigraphy in the diagnostic and prognostic evaluation of diabetic patients with suspected coronary artery disease and in screening high-risk asymptomatic diabetic patients.

Effect of long-term calcitonin administration on steroid-induced osteoporosis after cardiac transplantation.

BACKGROUND: Early, rapid bone loss and fractures after cardiac transplantation are well-documented complications of steroid administration; therefore, we undertook this study on the effects of long-term calcitonin on steroid-induced osteoporosis. METHODS: Twenty-three heart transplant recipients on maintenance immunosuppression with cyclosporine, mycophenolate mofetil and prednisone were retrospectively studied. All patients received long-term prophylactic treatment with elemental calcium and vitamin D. Twelve (52.2%) patients also received long-term intranasal salmon calcitonin, whereas 11 (47.8%) received none. Bone mineral density and vertebral fractures were assessed at yearly intervals. Statistical comparisons between each group's bone loss during the first year and in the early (1 to 3 years), intermediate (4 to 6 years) and late (7+ years) post-transplantation periods were done. RESULTS: Lumbar spine bone loss was significant during the early follow-up period in the group not receiving calcitonin (0.744 +/- 0.114 g/cm(2) vs 0.978 +/- 0.094 g/cm(2) [p = 0.002]). The calcitonin group showed bone mineral density (BMD) levels within normal average values throughout the study period. BMD increased in the no-calcitonin group during the intermediate (4 to 6 years) and late (7+ years) follow-up periods, with values approaching normal average and no significant difference between the 2 groups (0.988 +/- 0.184 g/cm(2) vs 0.982 +/- 0.088 g/cm(2) [p = 0.944] and 0.89 +/- 0.09 g/cm(2) vs 1.048 +/- 0.239 g/cm(2) [p = 0.474], respectively). CONCLUSIONS: Prophylactic treatment with intranasal salmon calcitonin prevents rapid bone loss associated with high-dose steroids early after cardiac transplantation. Long-term administration does not seem warranted in re-establishing BMD.

Tc-99m tetrofosmin reverse perfusion pattern with ST segment depression after dipyridamole infusion in a patient with unstable angina and no evident coronary artery stenoses.

Reverse redistribution is a well-known pattern found when performing thallium myocardial scintigraphy, and it has been implicated as an indicator of myocardial ischemia. Much more rarely, when using technetium compounds, which do not redistribute, a similar pattern is noted after the second injection of the radiotracer. This pattern has been termed "reverse perfusion pattern," and its full implications are not yet clear and are still being investigated.

Blood pressure elevation after phenylephrine infusion may adversely affect myocardial perfusion in patients with coronary artery disease.

BACKGROUND: Although blood pressure is a major determinant of myocardial oxygen-demand, little information is currently available regarding the changes in blood pressure (BP) during myocardial ischemia. Since BP elevation may cause left ventricular (LV) wall stress and an increase in oxygen demand, infusion of an alpha-adrenergic agonist, such as phenylephrine (PH), may provoke changes in myocardial perfusion in coronary artery disease (CAD) patients. As the effects of BP changes alone on myocardial perfusion have never been assessed by thallium-201 (Tl) scintigraphy, we investigated the effects of BP elevation after PH infusion, in order to study the hypothesis that pressure loading alone without increases in heart rate, may provoke transient impairment of regional myocardial perfusion, in CAD patients. PATIENTS AND METHODS: Forty-one (41) patients with angiographically documented CAD, aged 54+/-8 years, were included in our study. Each patient was given, without any complications, a PH (0.1 mg/ml) dose infused at a rate of 0.8 ml/mm, determined by a standardisation procedure and producing a mean blood pressure elevation of approximately 30% above baseline levels and a heart rate response to levels of no less than 50 bpm. One minute after the desired blood pressure and heart rate responses were reached, 2 mCi of Tl were injected and the PH infusion continued until the termination of the test. Tl scintigraphy was performed both 2 min after Tl injection and 4 h later, while the results were correlated to coronary angiography findings. RESULTS: PH scintigraphy produced 152 total defects. The mean perfusion defect size (%) was 14+/-12 and was directly related to the number of diseased vessels, i.e., 2% for one-vessel disease, 15% for two-vessel disease and 25% for three-vessel disease (P<0.05). The lowest percentage Tl activity values were 56+/-14 and were inversely related to the number of diseased vessels (P<0.01). The mean Tl lung counts/pixel values were 25+/-8 while it increased as the number of diseased vessels increased (P<0.01). The mean lung/heart ratio values were 0.31+/-0.08 while it increased as the number of diseased vessels increased (P<0.01). CONCLUSION: BP elevation after PH loading, produces a significant impairment of myocardial perfusion, that correlates well with the extend of angiographic findings.